Determinants of Glomerular Filtration Rate (GFR)

GFR should be ~100 mL/min

Calculating GFR
(140 – age) x lean body weight (kg) / sCr (umol/L)

What determines GFR

  1. Renal blood flow: effective circulating volume, cardiac output
  2. Resistance to flow: vascular tone of afferent and efferent arterioles
  3. Permeability of glomerular basement membrane

Drugs that increase GFR

  • Prostaglandin: vasodilator (afferent > efferent)
  • Angiotensin II: vasoconstrictor (efferent > afferent)
  • Norepinephrine: vasoconstrictor, increases blood pressure
  • ANP: afferent vasodilator, efferent vasoconstrictor

Drugs that decrease GFR

  • NSAIDs: afferent vasoconstriction
  • ACE Inhibitors: decrease efferent vasoconstriction
  • Angiotensin Receptor Blockers (ARBs): decrease efferent vasoconstriction
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2 thoughts on “Determinants of Glomerular Filtration Rate (GFR)

  1. Hi there – awesome site! I was hoping to use your determinants of GFR sketch for a talk I’m giving next week on kidney toxicity. Would it be possible to get a copy of the figure without the sketchymedicine.com watermark in the background? Perhaps at the side/bottom? Thanks and cheers!

  2. Wow, this is really wonderful. Thank you so much for sharing this, it makes science so much more easier to understand!

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