The nephron is composed of distinct areas that are specific to regulating different electrolytes.
An overview of nephron anatomy
Loop diuretics: blocks the sodium/potassium/chloride transporter in the ascending loop of Henle, potassium-wasting
Thiazide diuretics: blocks the sodium/chloride transporter in the distal tubule, potassium-wasting
Amiloride: directly blocks sodium channels in the collecting duct, potassium-sparing
Spironolactone: blocks the aldosterone receptors in the cortical collecting duct. This causes a decrease in sodium and water reabsorption and decreases potassium secreting (therefore is potassium-sparing)
I love all your drawings!!! It helps a lot!
Thanks! Let me know if there are any topics you want to see covered.
I love your animations- just discovered them and am covering Renal in med school right now. a huge help to understand the Big Picture! keep it up! we hit G.I. and Reproductive next .. haven’t seen if you cover any of those topics
Thanks, Miller. As for GI and reproductive, there are a couple images including blood supply to the GI tract and cholecystitis and a couple things on the menstrual cycle.
Not bad intro sketches. One mistake is under TAL of loop you marked the N/K ATPase as the reason for potassium lose. It is at N/K/Cl cotransporter because it is block by the loop diuretic like you have labeled. 25% of filtered K+ isn’t reabsorbed once blocked by a loop diuretic. Otherwise strong work.
Thanks! I by no means a nephrologist so I appreciate the clarification!